Clinical Studies - 𝐍𝐌𝐍活健齡 - 對抗衰老活得健康

有關NMN的人類/及動物之臨床實驗

2023年2月 The additive effects of nicotinamide mononucleotide and melatonin on mitochondrial biogenesis and fission/fusion, autophagy, and microRNA-499 in the aged rat heart with reperfusion injury

2023年2月 Nicotinamide Mononucleotide Alleviates Osteoblast Senescence Induction and Promotes Bone Healing in Osteoporotic Mice

2023年2月 Nicotinamide adenine dinucleotide metabolism and arterial stiffness after long-term nicotinamide mononucleotide supplementation: a randomized, double-blind, placebo-controlled trial

2023年2月 Melatonin/nicotinamide mononucleotide/ubiquinol: a cocktail providing superior cardioprotection against ischemia/reperfusion injury in a common co-morbidities modelled rat

2023年2月 Nicotinamide mononucleotide alters body composition and ameliorates metabolic disorders induced by a high-fat diet

2023年2月 Nicotinamide mononucleotide restores oxidative stress-related apoptosis of oocyte exposed to benzyl butyl phthalate in mice

2023年2月 NMN Alleviates NP-Induced Learning and Memory Impairment Through SIRT1 Pathway in PC-12 Cell

2023年2月 The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial

2023年2月 Nicotinamide Adenine Dinucleotide Augmentation in Overweight or Obese Middle-Aged and Older Adults: A Physiologic Study

2023年1月 Nicotinamide mononucleotides alleviated neurological impairment via anti-neuroinflammation in traumatic brain injury

2023年1月 Nicotinamide mononucleotide attenuates HIF-1α activation and fibrosis in hypoxic adipose tissue via NAD+/SIRT1 axis

2023年1月 Nicotinamide Mononucleotide Ameliorates Sleep Deprivation-Induced Gut Microbiota Dysbiosis and Restores Colonization Resistance against Intestinal Infections

2023年1月 Quantification of localized NAD+ changes reveals unique specificity of NAD+ regulation in the hypothalamus

2023年1月 Potential Synergistic Supplementation of NAD+ Promoting Compounds as a Strategy for Increasing Healthspan

2023年1月 Extracellular Vesicles from NMN Preconditioned Mesenchymal Stem Cells Ameliorated Myocardial Infarction via miR-210-3p Promoted Angiogenesis

2023年1月 Nicotinamide mononucleotide alleviates angiotensin II-induced human aortic smooth muscle cell senescence in a microphysiological model

2023年1月 Importance of NAD+ Anabolism in Metabolic, Cardiovascular and Neurodegenerative Disorders

2023年1月 Effects of nicotinamide mononucleotide on older patients with diabetes and impaired physical performance: A prospective, placebo-controlled, double-blind study

2022年12月 Nicotinamide Mononucleotide Ameliorates Silica-Induced Lung Injury through the Nrf2-Regulated Glutathione Metabolism Pathway in Mice

2022年12月 Nicotinamide Mononucleotide Administration Prevents Doxorubicin-Induced Cardiotoxicity and Loss in Physical Activity in Mice

2022年12月 Nicotinamide Mononucleotide Prevents Cisplatin-Induced Mitochondrial Defects in Cortical Neurons Derived from Human Induced Pluripotent Stem Cells

2022年12月 Modulation of sirtuins during monolayer chondrocyte culture influences cartilage regeneration upon transfer to a 3D culture environment

2022年12月 Mitochondrial Dysfunction and Therapeutic Perspectives in Cardiovascular Diseases

2022年12月 DNA damage contributes to age-associated differences in SARS-CoV-2 infection

2022年11月 Nicotinamide Mononucleotide Supplementation Improves Mitochondrial Dysfunction and Rescues Cellular Senescence by NAD+/Sirt3 Pathway in Mesenchymal Stem Cells

2022年11月 Nicotinamide Mononucleotide Protects against Retinal Dysfunction in a Murine Model of Carotid Artery Occlusion

2022年11月 Administration of nicotinamide mononucleotide improves oocyte quality of obese mice

2022年11月 NMN alleviates radiation-induced intestinal fibrosis by modulating gut microbiota

2022年11月 NMN ameliorated radiation induced damage in NRF2-deficient cell and mice via regulating SIRT6 and SIRT7

2022年11月 Declining muscle NAD+ in a hyperandrogenism PCOS mouse model: Possible role in metabolic dysregulation

2022年10月 A Narrative Review of Nicotinamide Adenine Dinucleotide (NAD)+ Intermediates Nicotinamide Riboside and Nicotinamide Mononucleotide for Keratinocyte Carcinoma Risk Reduction

2022年10月 The role of nicotinamide mononucleotide (NMN) in anti-aging, longevity, and its potential for treating chronic conditions

2022年9月 Nicotinamide Mononucleotide Prevents Retinal Dysfunction in a Mouse Model of Retinal Ischemia/Reperfusion Injury

2022年9月 Nicotinamide Mononucleotide Is Safely Metabolized and Significantly Reduces Blood Triglyceride Levels in Healthy Individuals

2022年9月 Treatment of inflammatory bowel disease: Potential effect of NMN on intestinal barrier and gut microbiota

2022年9月 Quantitative Acetylomics Reveals Dynamics of Protein Lysine Acetylation in Mouse Livers during Aging and Upon the Treatment of Nicotinamide Mononucleotide

2022年9月 LncRNA-ZFAS1 Promotes Myocardial Ischemia-Reperfusion Injury Through DNA Methylation-Mediated Notch1 Down-Regulation in Mice

2022年8月 Safety evaluation of β-nicotinamide mononucleotide oral administration in healthy adult men and women

2022年8月 Nicotinamide mononucleotide alleviates osteoblast senescence induction and promotes bone healing in osteoporotic mice

2022年8月 Nicotinamide mononucleotide ameliorates adriamycin-induced renal damage by epigenetically suppressing the NMN/NAD consumers mediated by Twist2

2022年8月 Supplementation with NAD + and Its Precursors to Prevent Cognitive Decline across Disease Contexts

2022年8月 Supplementation of nicotinamide mononucleotide improves the quality of postovulatory aged porcine oocytes

2022年8月 Nicotinamide mononucleotide ameliorates DNFB-induced atopic dermatitis-like symptoms in mice by blocking activation of ROS-mediated JAK2/STAT5 signaling pathway

2022年7月 Nicotinamide mononucleotide improves spermatogenic function in streptozotocin-induced diabetic mice via modulating the glycolysis pathway

2022年7月 Nicotinamide Mononucleotide Ameliorates Cellular Senescence and Inflammation Caused by Sodium Iodate in RPE

2022年7月 Combination of nicotinamide mononucleotide and troxerutin induces full protection against doxorubicin-induced cardiotoxicity by modulating mitochondrial biogenesis and inflammatory response

2022年7月 Administration of nicotinamide mononucleotide improves oocyte quality of obese mice

2022年7月 Nicotinamide Mononucleotide and Coenzyme Q10 Protects Fibroblast Senescence Induced by Particulate Matter Preconditioned Mast Cells

2022年6月 Unique Deep Radiomic Signature Shows NMN Treatment Reverses Morphology of Oocytes from Aged Mice

2022年6月 Nicotinamide Mononucleotide Administration Triggers Macrophages Reprogramming and Alleviates Inflammation During Sepsis Induced by Experimental Peritonitis

2022年6月 Metformin, Rapamycin, or Nicotinamide Mononucleotide Pretreatment Attenuate Cognitive Impairment After Cerebral Hypoperfusion by Inhibiting Microglial Phagocytosis

2022年6月 Nicotinamide mononucleotide supplementation improves the quality of porcine oocytes under heat stress

2022年6月 Nicotinamide Mononucleotide Administration Restores Redox Homeostasis via the Sirt3-Nrf2 Axis and Protects Aged Mice from Oxidative Stress-Induced Liver Injury

2022年6月 Nicotinamide mononucleotide supplementation protects the intestinal function in aging mice and D-galactose induced senescent cells

2022年6月 Nicotinamide mononucleotide reduces melanin production in aged melanocytes by inhibiting cAMP/Wnt signaling

2022年5月 The combination of nicotinamide mononucleotide and lycopene prevents cognitive impairment and attenuates oxidative damage in D-galactose induced aging models via Keap1-Nrf2 signaling

2022年5月 Nicotinamide Mononucleotide Administration Amends Protein Acetylome of Aged Mouse Liver

2022年5月 Distribution of Nicotinamide Mononucleotide After Intravenous Injection in Normal and Ischemic Stroke Mice

2022年5月 Nicotinamide mononucleotide ameliorates acute lung injury by inducing mitonuclear protein imbalance and activating the UPR mt

2022年5月 Chronic nicotinamide mononucleotide supplementation elevates blood nicotinamide adenine dinucleotide levels and alters muscle function in healthy older men

2022年5月 The combination of nicotinamide mononucleotide and lycopene prevents cognitive impairment and attenuates oxidative damage in D-galactose induced aging models via Keap1-Nrf2 signaling

2022年4月 NAD + Precursors Repair Mitochondrial Function in Diabetes and Prevent Experimental Diabetic Neuropathy

2022年4月 NAD +-boosting molecules suppress mast cell degranulation and anaphylactic responses in mice

2022年4月 Nicotinamide Mononucleotide Alleviates Cardiomyopathy Phenotypes Caused by Short-Chain Enoyl-Coa Hydratase 1 Deficiency

2022年4月 Treatment of SARS-CoV-2-induced pneumonia with NAD + and NMN in two mouse models

2022年4月 Oral Administration of Nicotinamide Mononucleotide Is Safe and Efficiently Increases Blood Nicotinamide Adenine Dinucleotide Levels in Healthy Subjects

2022年4月 The role of nicotinamide mononucleotide (NMN) in anti-aging, longevity, and its potential for treating chronic conditions

2022年4月 NAD + Anabolism Disturbance Causes Glomerular Mesangial Cell Injury in Diabetic Nephropathy

2022年4月 Nicotinamide mononucleotide alleviates heat stress-induced oxidative stress and apoptosis in BMECs through reducing mitochondrial damage and endoplasmic reticulum stress

2022年4月 Multispectral autofluorescence characteristics of reproductive aging in old and young mouse oocytes

2022年4月 NAD+ ameliorates endotoxin-induced acute kidney injury in a sirtuin1–dependent manner via GSK-3β/Nrf2 signalling pathway

2022年4月 Intestinal Epithelial NAD+ Biosynthesis Regulates GLP-1 Production and Postprandial Glucose Metabolism in Mice

2022年4月 NAMPT mitigates colitis severity by supporting redox-sensitive activation of phagocytosis in inflammatory macrophages

2022年4月 NAD supplementation improves mitochondrial performance of cardiolipin mutants

2022年3月 Antioxidant effect of nicotinamide mononucleotide in tendinopathy

2022年3月 Restoring nuclear entry of Sirtuin 2 in oligodendrocyte progenitor cells promotes remyelination during ageing

2022年3月 Mitochondrial dysregulation occurs early in ALS motor cortex with TDP-43 pathology and suggests maintaining NAD+ balance as a therapeutic strategy

2022年3月 Nicotinamide mononucleotide increases cell viability and restores tight junctions in high-glucose-treated human corneal epithelial cells via the SIRT1/Nrf2/HO-1 pathway

2022年2月 Effect of 12-Week Intake of Nicotinamide Mononucleotide on Sleep Quality, Fatigue, and Physical Performance in Older Japanese Adults: A Randomized, Double-Blind Placebo-Controlled Study

2022年2月 PINK1-parkin-mediated neuronal mitophagy deficiency in prion disease

2022年1月 Nicotinamide mononucleotide promotes pancreatic islet function through the SIRT1 pathway in mice after severe burns

2022年1月 NMN recruits GSH to enhance GPX4-mediated ferroptosis defense in UV irradiation induced skin injury

2021年12月 Pretreatment with Nicotinamide Mononucleotide Increases the Effect of Ischemic-Postconditioning on Cardioprotection and Mitochondrial Function Following ex vivo Myocardial Reperfusion Injury in Aged Rats

2021年11月 Nicotinamide mononucleotide attenuates doxorubicin-induced cardiotoxicity by reducing oxidative stress, inflammation and apoptosis in rats

2021年11月 The Impacts of Short-Term NMN Supplementation on Serum Metabolism, Fecal Microbiota, and Telomere Length in Pre-Aging Phase

2021年11月 NAD + Metabolism in Cardiac Health, Aging, and Disease

2021年11月 Long-term treatment of Nicotinamide mononucleotide improved age-related diminished ovary reserve through enhancing the mitophagy level of granulosa cells in mice

2021年10月 β-Nicotinamide Mononucleotide (NMN) Administrated by Intraperitoneal Injection Mediates Protection Against UVB-Induced Skin Damage in Mice

2021年10月 Nicotinamide mononucleotide: An emerging nutraceutical against cardiac aging?

2021年7月 NMN Maintains Intestinal Homeostasis by Regulating the Gut Microbiota

2021年7月 Nicotinamide Mononucleotide Prevents Cisplatin-Induced Cognitive Impairments

2021年7月 Nicotinamide mononucleotide supplementation enhances aerobic capacity in amateur runners: a randomized, double-blind study

2021年6月 The new insight into extracellular NAD + degradation-the contribution of CD38 and CD73 in calcific aortic valve disease

2021年6月 Pre-emptive Short-term Nicotinamide Mononucleotide Treatment in a Mouse Model of Diabetic Nephropathy

2021年6月 Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women

2021年6月 Nicotinamide mononucleotide attenuates isoproterenol-induced cardiac fibrosis by regulating oxidative stress and Smad3 acetylation

2021年6月 Nicotinamide mononucleotide augments the cytotoxic activity of natural killer cells in young and elderly mice

2021年5月 Nicotinamide mononucleotide ameliorates senescence in alveolar epithelial cells

2021年4月 Nicotinamide mononucleotide and melatonin counteract myocardial ischemia-reperfusion injury by activating SIRT3/FOXO1 and reducing apoptosis in aged male rats

2021年3月 Nicotinamide Mononucleotide Combined With Lactobacillus fermentum TKSN041 Reduces the Photoaging Damage in Murine Skin by Activating AMPK Signaling Pathway

2021年3月 Nicotinamide Mononucleotide Attenuates Renal Interstitial Fibrosis After AKI by Suppressing Tubular DNA Damage and Senescence

2021年2月 Nicotinamide Mononucleotide Restores the Meiotic Competency of Porcine Oocytes Exposed to Ethylene Glycol Butyl Ether

2021年2月 Nicotinamide Mononucleotide Alleviates Hyperosmolarity-Induced IL-17a Secretion and Macrophage Activation in Corneal Epithelial Cells/Macrophage Co-Culture System

2021年1月 Generation and assessment of high-quality mouse oocytes and embryos following nicotinamide mononucleotide administration

2021年1月 Nicotinamide mononucleotide inhibits hepatic stellate cell activation to prevent liver fibrosis via promoting PGE 2 degradation

2020年12月 Neuroprotective effects and mechanisms of action of nicotinamide mononucleotide (NMN) in a photoreceptor degenerative model of retinal detachment

2020年12月 NMN透過改善粒線體功能失常，減低感染新型冠狀病毒的機會及嚴重性

2020年11月 NMN在動物實驗能逆轉蛋白質穩態的喪失，減低腎臟衰老

2020年11月 NMN在動物能成為預防肝纖維化的新一代治療

2020年10月 NMN能有效增強糖尿動物角膜上皮破損的癒合及神經康復

2020年10月 NMN在動物實驗能逆轉年老心臟的收縮功能障礙

2020年8月 NMN能逆轉動物心血管內皮細胞功能失調

2020年8月 NMN能逆轉動物的卵母細胞衰老理論上能改善人類女性不育

2020年8月 NMN在動物能有效抑制及減少卵母細胞DNA異變有望成為女性不育治療方案之一育

2020年7月 NMN在動物能治療服用類固醇所導致的骨質疏鬆

2020年7月 NMN能有效減低動物嚴重低血糖所引致的腦細胞受損

2020年7月 NMN可能對人類老年性黃斑部病變有療效

2020年6月探討NMN治療神經醫學疾病的可能性

2020年5月 NMN對動物因糖尿病腦部失憶及失智有預防療效

2020年4月探討NMN對各種不同疾病的治療可行性

2020年4月 NMN能有效降低UVB照射引發的角膜內皮細胞凋亡

2020年4月 NMN在年邁動物能促進神經血管再生

2020年4月 NMN在動物能減輕母體過重引致的代謝疾病

2020年3月 NMN能有效改善動物顱內出血問題並保護腦組織

2020年3月 NMN在動物能治療急性腦損傷和神經退行性疾病

2020年2月 NMN在動物能有效地治療抑鬱症

2020年2月 NMN可使衰老動物的卵母細胞質量恢復活力，從而導致生育力恢復

2020年2月 NMN對動物能有效防止角膜內皮細胞凋亡

2020年2月 NMN對動物能搶救神經血管功能，增加腦血流量並改善認知任務的表現

2020年1月 NMN在動物能改善因承受過大壓力而引致的心肌細胞肥大

以下是正在進行中/ 已研究發報成果的人類臨床實驗 :

2019年11月 NMN人類臨床實驗服用後沒有不良反應

2019年5月總結NMN對代謝疾病的療效及討論其人類臨床實驗

2019年1月探討NMN對保護心臟,預防糖尿,預防認知障礙,及肥胖引起的併發症等病症的治療效果

2017年7月人類服用NMN對心血管及代謝症的影響

2016年3月日本慶應義塾大学聯同美國聖路易斯華盛頓大學開始了第一期關於NMN人類臨床實驗

全球各地已有不少醫生及科學家正開始對 NMN 進行人類臨床研究。從多次已知的動物臨床效果分析，科學家都認為 NMN 對於人類維護健康、對抗衰老的成效是樂觀和正面的。相信人類臨床結果面世的時間已不遠矣。

筆者是註冊醫生，NMN對人類健康的幫助和延遲人類衰老的成效我深信不疑。我和家人每天服用NMN已有相當的時間。我也建議大家今天起開始服用。

2019年5月NMN對動物腦血管疾病有幫助並能改善腦力

2019年4月NMN對動物增進間充質幹細胞對骨質增生的療效

2019年3月建議NMN應被列為治療人類心血管病老化的嚴謹方案之一

2019年3月NMN可能對動物或人類骨質疏鬆有療效

2019年3月NMN可能是動物糖尿腎病未來有效的治療

2019年3月探討NMN對抗衰老及缺血狀況治療的原理

2019年2月NMN對動物線粒體疾病有療效

2019年1月NMN極有潛力醫治神經退化性疾病

2018年11月NMN對動物腦部增加認知能力

2018年10月NMN能有效改善動物鋁質導致的骨質疏鬆病

2018年10月NMN在動物能有效保護椎間盤的退化

2018年9月NMN大大增加了動物在失血性休克的存活機會

2018年8月NMN對動物有保護心臟的作用

2018年6月NMN能有效改善動物視網膜表皮組織老化

2018年3月NMN能有效對動物增加各處器官的血流量

2017年12月NMN/Nicotinamide Riboside可能對人類認知障礙症(俗稱老人痴呆)有療效

2017年11月NMN對動物葡萄糖耐受不良及減脂有療效

2017年11月NMN對動物糖尿病腎病有療效

2017年11月NMN對動物心臟衰竭有療效

2017年11月NMN能有效減低對動物腦血管栓塞治療所引起的併發症

2017年8月NMN/Nicotinamide Riboside能有效減低對動物肌肉新陳代謝引致的衰老

2017年8月NMN能有效保護動物免受急性腎損傷的傷害

2017年7月NMN對動物大腸退化有療效

2017年7月NMN能有效改善動物心肌症的心臟功能

2017年4月NMN能有效減低對動物出血性中風的腦水腫和腦細胞死亡

2017年4月NMN能有效改善動物認知障礙症(俗稱老人痴呆)的各種病理影響

2017年3月NMN能有效在動物保護視網膜病變

2016年12月NMN能有效改善動物年老時的體能，新陳代謝及視力，並能減低體重，血脂及糖尿病

2016年11月NMN能強烈保護動物的局部性腦缺血帶來的傷害

2016年8月NMN能有效改善肥胖動物的各種代謝指標，效果可比美做運動

2016年7月NMN對動物認知障礙(老人癡呆)有良好療效

2016年6月NMN能逆轉動物血管老化

2014年7月NMN對動物柏金遜病有療效

2014年6月NMN對動物心臟缺血有保護作用

2011年10月 NMN能有效改善動物因年老或飲食誘發的二型糖尿