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The Key to Winning the Battle of Immunity

Countries around the world are pooling resources to combat the COVID-19 pandemic; similarly, our bodies, when faced with the invasion of foreign viruses, will also concentrate resources to wage an immune battle. NAD+ is not only the source of our life, providing energy to cells for normal operation and gene repair; recent clinical research has shown that NAD+ also gives cells enough resilience to fight against foreign viral infections, reducing the damage caused by foreign viruses to the body.

The study found in cells and animal tissues infected with the coronavirus and COVID-19 that the attack of the COVID-19 virus on cells causes NAD+ levels to rapidly decline, simultaneously triggering a strong demand in the body for NAD+ to fight the invasion of foreign viruses. The study found that supplementing the body's NAD+ levels can enhance the body's immunity to the coronavirus and other viral infections. Infected cells will continuously consume NAD+ in an attempt to resist the virus; meanwhile, the virus will attempt to hinder the body's immune resistance and massively reproduce the virus through another set of genes.

The study was jointly conducted by three American universities, University of Iowa, Oregon Health & Science University, and University of Kansas, and found that coronaviruses, including SARS-CoV-2 and COVID-19, greatly disrupt the body's NAD+ balance. Coronaviruses deplete and suppress the normal levels of NAD+ in the human body by utilizing multiple different PARP genes, and NAD+ is an essential part of maintaining innate immune responses and fighting against viruses. The study found that in the lung tissues of those who unfortunately died from COVID-19, the coronavirus caused a significant decrease in NAD+, preventing the body from producing more NAD+ and weakening the body's ability to fight against the virus. In other words, our immune mechanism to resist external pressures (a variety of physiological stresses), including viral invasions (viral infections), loses function. The data shows that preventing the massive loss of NAD+ or increasing the body's NAD+ levels are both very beneficial to cells, and more research will follow. In addition to hijacking our immune mechanisms, COVID-19 coronaviruses also release a large amount of pro-inflammatory molecules in the later stages to attack the lungs, causing some patients to develop fatal acute respiratory distress syndrome. The study shows that NAD+ plays a very important role in balancing the immune system, regulating Sirtuins to coordinate the transmission of messages such as pro-inflammatory molecules.

On April 20, 2020, Dr. Robert J. Huizenga from Cedars-Sinai Medical Center in Los Angeles, USA, published a medical report on the treatment of a severe COVID-19 patient, who showed significant clinical improvement after oral NMN treatment. The patient, who developed severe inflammation and breathing difficulties and required a respiratory device 11 days after diagnosis, was immediately sent to the aforementioned hospital. The doctor prescribed NMN treatment for two consecutive days, successfully improving the patient's respiratory problems and increasing the white blood cell count in the body within 12 hours. Within 36 hours, the patient's blood oxygen level and body temperature returned to normal levels, and the inflammation gradually subsided. The patient was discharged on the 17th day and fully recovered by the 23rd day. NMN treatment was also used in two other elderly confirmed COVID-19 patients, with significant clinical improvements in fever, chest pressure, cough, headache, and low energy issues recorded within 36-48 hours. For more details, please refer to the original English medical report here.

The report concluded: NMN directly supplements the body's NAD+ levels, which is significant for slowing down the decline of tissue/organ function related to aging, enhancing immunity, regulating the risk of excessive immune cell response - cytokine storm, promoting blood circulation, and protecting kidneys, liver, and brain from disease impact. NMN has shown significant positive clinical treatment effects.

聽聽 Prof. David Sinclair 親自講解 NMN/NAD+ 增強免疫力與戰勝Covid-19的關鍵; 除上述三所大學的研究和真實Covid-19患者醫療報告外, 請<於此>參閱相關醫學文獻 。

Listen to Prof. David Sinclair personally explain the key role of NMN/NAD+ in enhancing immunity and overcoming Covid-19. In addition to the research from the above three universities and the real medical reports of Covid-19 patients, please refer to relevant medical literature here.

<Source from, respect and credit to https://www.youtube.com/user/FamilyOffice/about>

Excerpts from the original text can be found in this medical literature here.

Thus, during aging, a decline in NAD+ and the known mislocalization of SIRT1 and SIRT6 across the genome during aging [68, 109], could be major contributors to the age-dependency of COVID-19 symptoms. Given the increasing evidence that lower NAD+ levels in the lung and vascular endothelium contribute to poor COVID-19 outcomes, NAD boosters, such as the NAD+ precursors NMN and NR [110], have been suggested as first-line treatments against COVID-19, especially aged patients [56]. 

To add again, NAD+ cannot be supplemented by direct intake of NAD+. For more details, please refer to this article. NAD+ can only be supplemented through NAD+ booster precursors NMN and NR, so please carefully choose NAD+ supplements. Products on the market that claim NAD+ is more direct than NMN and NR in increasing NAD+ levels are believed to have violated the Regulations on Product Descriptions for unfair business practices.

What is NAD+?

The full name of NAD+ is Nicotinamide Adenine Dinucleotide, a naturally occurring substance in all living organisms. NAD+ plays an indispensable role in the body, serving as fuel for all cells, responsible for energy production, activating longevity genes (Sirtuins), repairing cellular genetic damage, coordinating multiple epigenetic message transmission channels related to anti-aging, reducing inflammation, and maintaining the balance of all mechanisms in the body.

In children and during youth, NAD+ levels in the body are very high. However, as we age into middle and old age, the level of NAD+ in the body decreases significantly. This is a natural part of the aging process, but research suggests that maintaining higher levels of NAD+ can help promote health and longevity. Supplements like NMN and NR are being studied for their potential to boost NAD+ levels in the body, potentially offering a range of health benefits.

How to increase NAD+ levels in the body?

NAD+ can be supplemented by orally taking the NAD+ precursor NMN. In the human body, NAD+ is derived from Nicotinamide Mononucleotide (NMN). Supplementing NMN in the body is the safest, most direct, and effective method to increase the level of NAD+ in the body. For more detailed information, please refer to here.

If you want to learn more or wish to purchase NMN for healthy aging, feel free to contact us at (852) 3996 9618 or WhatsApp at (852) 6938 6380.

Reference:

  1. Huizenga, Robert, Dramatic Cytokine Storm Reversal with an Over the Counter NMN Cocktail (April 20, 2020).
  2. Heer, C.D., et al., Coronavirus Infection and PARP Expression Dysregulate the NAD Metabolome: A Potentially Actionable Component of Innate Immunity. bioRxiv, 2020: p. 2020.04.17.047480.
  3. https://finance.yahoo.com/news/chromadex-commits-covid-19-research-103200816.html
  4. Wang, X., et al., Sirtuins and Immuno-Metabolism of Sepsis. Int J Mol Sci, 2018. 19(9).
  5. Kouhpayeh, S., et al., The Molecular Story of COVID-19; NAD+ Depletion Addresses All Questions in this Infection. Preprints, 2020.
  6. Shi, Y., et al., COVID-19 infection: the perspectives on immune responses. Cell Death Differ, 2020.